CONICET | Buscador de Institutos y Recursos Humanos

food additives, therapeutic drugs, etc. The liver is considered the primary site for drug metabolismand elimination pathways, consisting in uptake, phase I and II reactions, and efflux processes,usually acting in this same order. Modulation of biotransformation and disposition of drugsof clinical application has important therapeutic and toxicological implications. We hereprovide a compilation and analysis of relevant, more recent literature reporting hormonal regulationof hepatic drug biotransformation and transport systems. We provide additional informationon the effect of hormones that tentatively explain differences between sexes. A brief discussionon discrepancies between experimental models and species, as well as a link between genderrelateddifferences and the hormonal mechanism explaining such differences, is also presented.Finally, we include a comment on the pathophysiological, toxicological, and pharmacologicalrelevance of these regulations. C 2013 American Physiological Society. Compr Physiol 3:1-20,2013.