Hybrid Thermosensitive-Nanogels based on N-vinylcaprolactam

SONZOGNI, ANA S.; GONZALEZ, VERÓNICA D.G.; VAILLARD, SANTIAGO E.; PASSEGGI, MARIO C.G. (H); GUGLIOTTA, LUIS M.; MINARI, ROQUE J.

Porto de Galinhas, PE

Simposio; XIV Simposio Latinoamericano de Polímeros / XII Congreso Iberoamericano de Polímeros; 2014

Asociación Brasilera de Polímeros

This work presents a semibatch strategy to produce hybrid nanogels with core-shell morphology. The synthesized nanogels have a core of poly(N-vinylcaprolactam) (PVCL), a biocompatible polymer with a phase transition close to the physiological temperature, and a shell of poly(butyl acrylate) (PAcBut) that provides the properties of adhesiveness and film formation. These nanogels could be directly used in transdermal drug release, without requiring a support and adhesive matrix. Morphology, mean particle diameter and thermal response of the nanogels were evaluated along the work.