INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Intra-arterial Controlled Release from Hollow Cylindrical Implants
Autor/es:
J.C.D. IBARRA; I.M. HELBLING; J.A. LUNA
Lugar:
Suzhou
Reunión:
Simposio; 4th Annual Symposium of Drug Delivery Systems (SDDS); 2014
Institución organizadora:
BIT Life Sciences
Resumen:
New implants for controlled release of oncological
drugs to minimize side effects of chemotherapy and to achieve localized release
near tumors were investigated. A site-specific delivery system using matrices
of ethylene vinyl acetate copolymer (EVA) loaded with paclitaxel for
intraarterial implantation was designed. The hollow cylindrical polymeric
matrices were fabricated by a hot-melt extrusion procedure. Characterization of
controlled release system was carried out to determine the initial drug
content, paclitaxel diffusion coefficient in the matrix and paclitaxel solubility
in EVA and in release medium. The in vitro release of paclitaxel from EVA matrices were conducted using two release
medium: ultra filtered water with an ethanol content of 20% V/V and PBS + SDS
0.3% w/V. Results showed that release follows typical matrix-type release
kinetic. At day 15, more than 85 % of initial content was released. In
addition, hollow cylindrical matrices were placed inside pig heart arteries and
in vitro release test were conducted as before. Besides, permeation studies
were performed to determine paclitaxel diffusion coefficient in the pig artery.
Results showed a lag time in release profiles. Lag time duration was directly
related to the thickness of the arterial wall. However, arterial wall do not
control paclitaxel delivery. It acts as a non-controlling release barrier. This
could be due mainly to the higher paclitaxel diffusion coefficient in the
artery compared with that in the matrix. Results obtained in the present
contribution show a potential use of EVA-paclitaxel matrix systems for
endovascular treatment.