Dynamic Analysis of a Single-Nephron Model due to Changes in Efferent Blood Viscosity

ESPINEL, ANDREA; P. S. RIVADENEIRA; V. COSTANZA; AMORENA, CARLOS

Antalya

Simposio; 4th Interdisciplinary Symposium on Chaos and Complex Systems; 2012

Ýstanbul Kültür Üniversitesi

In this paper, a mathematical model of the dynamics of a single-nephron function relating glomerulo-tubular balance, tubule-glomerular feedback, and peritubular blood viscosity is developed. Based upon experimental data, the model shows that complex behaviors of the nephron can be modulated by changes in the efferent arteriole blood viscosity. The main hypothesis is that the reabsorbed mass flow is modulated by the hematocrit of the efferent arteriole, in addition to the Starling forces. From a mathematical perspective, these behaviors can be explained by a bifurcation diagram analysis where the efferent blood viscosity is taken as the bifurcation parameter. This analytical description allows to predict changes in proximal convoluted tubule reabsorption, following changes in peritubular capillary viscosity generated by periodic changes in the glomerular filtration rate. Thus, the model links the tubule-glomerular feedback with the glomerular tubular balance.