INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
The optimization of an intravaginal ring releasing progesterone using a mathematical model
Autor/es:
I.M. HELBLING; J.C.D. IBARRA; J.A. LUNA
Revista:
PHARMACEUTICAL RESEARCH
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Lugar: New York; Año: 2014 vol. 31 p. 795 - 808
ISSN:
0724-8741
Resumen:
Purpose Progering® is the only intravaginal ring intended for contraception
therapies during lactation. It is made of silicone and releases
progesterone through the vaginal walls. However, some drawbacks
have been reported in the use of silicone. Therefore, ethylene vinyl
acetate copolymer (EVA) was tested in order to replace it.
Methods EVA rings were produced by a hot-melt extrusion procedure.
Swelling and degradation assays of these matrices were
conducted in different mixtures of ethanol/water. Solubility and partition
coefficient of progesterone were measured, together with the
initial hormone load and characteristic dimensions. A mathematical
model was used to design an EVA ring that releases the hormone at
specific rate.
Results An EVA ring releasing progesterone in vitro at about
12.05±8.91 mg day−1 was successfully designed. This rate of
release is similar to that observed for Progering®. In addition, it
was observed that as the initial hormone load or ring dimension
increases, the rate of release also increases. Also, the device lifetime
was extended with a rise in the initial amount of hormone load.
Conclusions EVA rings could be designed to release progesterone
in vitro at a rate of 12.05±8.91 mg day−1. This ring would
be used in contraception therapies during lactation. The use of
EVA in this field could have initially several advantages: less initial
and residual hormone content in rings, no need for additional
steps of curing or crosslinking, less manufacturing time and costs,
and the possibility to recycle the used rings.