Hipothyroidism in both HIV-Infected and uninfected male and female adult subjects

PRENER PAOLA; SUESCUN MARÍA OLGA; MELILLO CLAUDIA

Ciudad Autónoma de Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigacion Clínica y otras Sociedades de Biociencias

HYPOTHYROIDISM IN BOTH HIV-INFECTED AND UNINFECTED MALE AND FEMALE ADULT SUBJECTSAbstract: The prevalence of functional diseases of the thyroid gland is high in the general population. It is more common in women than in men. International studies show a prevalence of hypothyroidism in adults in a range of 4% to 17%. Human immunodeficiency virus (HIV) infection is a disease that affects endocrine function. Thyroid dysfunction is common in HIV-infected patients. The purpose of this study was to compare the frequency of hypothyroidism among male and female in both HIV positive and negative adults patients treated in a public hospital in La Plata. A total of 147 HIV positive patients (HIVp), 62 women and 85 men with a mean age of 41 years, and 280 HIV negative (HIVn), 124 men and 156 women with an average age of 46 years, were studied. Serum?s Thyrotrophin (TSH), free thyroxine (T4L), antithyroglobulin (a-TG) and anti-thyroperoxidase (a-TPO) antibodies were measured by chemiluminescence in an ARCHITECTἱ System (Abbott Diagnostics). The results showed that the frequency of hypothyroidism in HIVp was 29% (43/147) and 9.6% (27/280) in HIVn. Hypothyroidism was detected in 15 women and 28 HIVp men, and in 17 women and 10 HIVn men. TSH levels in HIVp women were (X ± SD) 2.98 ± 2.61, and 3.73 ± 3.04 μIU / mL in men. In HIVn were 2.98 ± 4.28 in women and 2.93 ± 5.84 μIU / mL in men. In HIVn women, serum T4L was higher than in men (p