Native American, European and African ancestry from genotype by sequencing in Argentinean populations

MUZZIO MARINA; MOTTI JOSEFINA MB; COOKE T; JURADO MEDINA LAURA; YEE MC; ADAMS A; BELTRAMO JULIETA; SANTOS MARÍA R; RAMALLO VIRGINIA; SCHWAB MARISOL; CORNEJO O; BAILLIET GRACIELA; KENNY E; BRAVI, CLAUDIO M.; BUSTAMANTE CD

Boston

Congreso; American Society of Human Genetics 63rd Annual Meeting; 2013

American Society of Human Genetics

In this work we aim to describe the demographic history and populationstructure of Argentina, by analyzing a collection of 2904 DNA samples from15 dispersed regions in Argentina, from the Andean populations in theNorthwest to the river lands of the Northeast. Argentina has history of broadcultural diversity, which included hunter-gatherers and agro-pastoralists tothe expansion of the Inca Empire, the Spanish arrival, slave trade from Africaand the European migration between the mid XIXth and XXth centuries. Thusfar, we have 390 genotypes defined from the Illumina Exome Array 250Kand 89 genome-wide sequences from a genotype-by-sequencing strategywe developed, which covers 1.5% of the genome. We will continue tosequence more samples from our collection of 2904 participants from 15Argentinean populations. From our preliminary data, we have identifiedproportions and patterns of European, African and Indigenous Americanancestry in the Argentinean cohort via local ancestry inference and founda correlation between latitude and proportion of Native American ancestry,where the highest proportion corresponds to the northernmost populations,(where it averages 75.06%) descending towards the center of Argentina(averaging 34.02%). We will focus on our sequencing data and compare itto full genomes of Native Americans, studying the genomic tracts of NativeAmerican ancestry for fine-scale examination of sub-continental structure.