Study of the neurobiological mechanisms which regulate reward eating behaviors during caloric restriction: role of the hormone ghrelin and its receptor GHSR

DANIELA CASSANO, FRANCO BARRILE, MIRTA REYNALDO, GUADALUPE GARCÍA ROMERO, MARIO PERELLÓ.

Buenos Aires

Congreso; XXXVII SAN 2022 Annual Meeting; 2022

Ghrelin is a stomach-derived hormone that acts via the growth hormone secretagogue receptor (GHSR). GHSR is expressed in the arcuate nucleus (ARC), in the lateral hypothalamic area(LHA) and in the dopamine neurons of the ventral tegmental area (VTA) that innervate the nucleus accumbens (Acb). Since plasma ghrelin levels increase under calorie restriction (CR), GHSR signaling could act in the mesolimbic pathway and affect reward-related behaviors. We studied theneurobiological mechanisms by which GHSR controls the consummatory behavior of palatable stimuli under CR.