Spexin modulate inguinal white adipose tissue thermogenesis upon cold exposure

GIORDANO, ALEJANDRA PAULA; GIOVAMBATTISTA, ANDRÉS; ZUBIRÍA, MARÍA GUILLERMINA; CASTRO, PATRICIA; GAMBARO, SABRINA ELIANA; HARNICHAR, ALEJANDRO EZEQUIEL

Congreso; Reunión Anual de Sociedades de Biociencia 2022; 2022

Spexin is an anorexigenic adipokine that has multiple physiological function such as anti-obesogenic properties, anxiolytic, among others but there are not current information about SPX role on white adipose tissue (AT) thermogenesis. So, male mice were treated or not (CTR) with SPX for 10 days (29ug/kg/day; SPX) and at day 3 some animals were kept at RT and other at 4°C during 7 days (CTR-C; SPX-C) for thermogenesis induction. In this study, Inguinal AT was collected and processed for different determinations. Metabolic profile was previously reported. mRNA expression of UCP1, SPX and its receptor GALR2 showed interaction between variables (Two-way-anova; Cold x SPX). UCP1 post test showed an increase in CTR-C group vs. CTR and decreased in SPX-C vs. CTR-C (P