Genetic variation of OPRM1, OPRK1, and COMT genes and their posible association with oral pain in a population from Argentine.

HOHL DIANA MARIA; GONZÁLEZ REBECA; CECILIA INES CATANESI; RAGGIO MARIA CELESTE; GLESMANN LAURA ANGELA

Journal of Oral & Facial Pain and Headache

Quintessence Publishing Co

Lugar: Chicago; Año: 2018 vol. 32 p. 367 - 374

2333-0384

Aims: to analyze in the population of Resistencia the variation for three genes involved in the control of pain pathways, including two genes coding for opioid receptors, OPRM1 and OPRK1, and the gene COMT, which codes for an important enzyme in the control of neurotransmission. Also, to evaluate the association of these genes with oral pain and requirement of analgesia for oral pain in the population under study.Methods: 134 volunteer donors from Resistencia and, for comparison, 27 donors from Wichí community, were analyzed for 13 SNPs and 1 Indel localized in the 3 genes by PCR-RFLP or standard PCR and electrophoresis. All 134 individuals from Resistencia provided biological samples for DNA analysis, while a subset of 81 of them agreed to answer a questionnaire for taking part in an association analysis. A possible association between genetic variation and: self-reported ethnic origin, oral pain, and requirement of analgesia was performed.Results: significant differences were found in the comparison with populations from other continents, and also between our two populations (p