IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Leptin activates oxytocin neurons of the hypothalamic paraventricular nucleus in both control and diet-induced obese rodents
Autor/es:
PERELLO M; RAINGO J
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2013 p. 59625 - 59626
ISSN:
1932-6203
Resumen:
The adipocyte-derived hormone leptin acts in the brain to reduce body
weight and fat mass. Recent studies suggest that parvocellular oxytocin
(OXT) neurons of the hypothalamic paraventricular nucleus (PVN) can
mediate body weight reduction through inhibition of food intake and
increased energy expenditure. However, the role of OXT neurons of the
PVN as a primary target of leptin has not been investigated. Here, we
studied the potential role of OXT neurons of the PVN in leptin-mediated
effects on body weight regulation in fasted rats. We demonstrated that
intracerebroventricular (ICV) leptin activates STAT3 phosphorylation in
OXT neurons of the PVN, showed that this occurs in a subpopulation of
OXT neurons that innervate the nucleus of the solitary tract (NTS), and
provided further evidence suggesting a role of OXT to mediate leptin's
actions on body weight. In addition, our results indicated that OXT
neurons are responsive to ICV leptin and mediate leptin effects on body
weight in diet induced obese (DIO) rats, which are resistant to the
anorectic effects of the hormone. Thus, we conclude that leptin targets a
specific subpopulation of parvocellular OXT neurons of the PVN, and
that this action may be important for leptin's ability to reduce body
weight in both control and obese rats.