IMBICE   05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Rapid evolution of cytochrome c oxidase subunit II in camelids (Tylopoda, Camelidae)
Autor/es:
F DI ROCCO, G PARISI, A ZAMBELLI, L VIDAL RIOJA
Revista:
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Editorial:
Springer Netherlands
Referencias:
Año: 2006 p. 293 - 298
ISSN:
0145-479X
Resumen:
Within Cetartiodactyl species, both New and Old
World camelids are uniquely adapted to the extremely hot
and dry climates of African-Asian territories and to the high
altitude cold and hypoxic environment of the whole Andean
area. In order to investigate the potential association
between these particular adaptations and mitochondrial aerobic
energy production, we examined the camelid genes of
cytochrome c oxidase subunits I, II, and III and the replacement
of amino acids inferred. We found that all subunits
had undergone a number of replacements in sites otherwise
conserved in other cetartiodactyls. Changes of COXI and
COXIII were mainly located in the transmembrane helices
of proteins. For COXII, although most of the changes did
not occur in sites directly involved in electron transfer, a
shift of D by T at 115 position of Old World camelid might
modify electrostatic interactions with cytochrome c. COXII
also showed an increased relative evolutionary rate respect
to other cetartiodactyls compared.