Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina

CAMPAÑA H; PAWLUK MS; LOPEZ CAMELO JS; ECLAMC GROUP

ARCHIVOS ARGENTINOS DE PEDIATRIA

SOC ARGENTINA PEDIATRIA

Año: 2010 vol. 108 p. 409 - 417

0325-0075

Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina]. [Article in Spanish] Campaña H, Pawluk MS, López Camelo JS; Grupo de Estudio del ECLAMC. Collaborators (61) Carvallo IG, Minoli B, Fuentes ML, Rittler M, Rottenberg D, Petracchi F, Cosentino VR, Bosano B, Aiello H, Inés Di Giano L, Jewtuszyk MA, Lapunzina P, Quiroga JA, Bisbal M, Iraira C, Lerner M, Aguilar PG, Roubicek M, Rivelis C, Mussi MN, Schneider C, Garbaccio E, Ermini M, Uranga A, Medina A, Deguer C, Passarini R, Crispino PM, Mores FJ, Carciochi ML, Argüello CD, Cárpena L, Izquierdo M, Misisian AP, Echegaray MA, Pizarro CB, Ponce F, Negri CJ, Marsano M, De Rosas C, Menzio M, Diorio L, Cardetti M, Sirabo F, Ibáñez OJ, Picón C, Mayer MC, Saleme CM, Quinteros CR, Carrizo S, Moreno E, Hernández E, Lombardelli R, Mereb JC, Pedrozo BG, Raineri A, Prefumo LD, Coria R, Salmoni M, Andrade S, Dodero NR. Source Instituto Multidisciplinario de Biología Celular, CONICET, La Plata, Argentina. Abstract OBJECTIVE: The aim of the present work was to estimate the frequency of 27 birth defects in 7 geographical regions of Argentina. MATERIAL AND METHODS: Observational, cross-sectional, descriptive design. A sample of 21,844 new born with birth defects was selected, ascertained from 855,220 births, between 1994 and 2007, in 59 hospitals belonging to the ECLAMC network. In order to identify regions of high frequency a Poisson regression was used, adjusted by different hospitals from the same region. The model included a time variable to detect secular trends and 6 dummy variables for 7 predefined geographical regions: Metropolitana (MET); Pampa (PAM); Centro (CEN); Cuyo (CUY); Noroeste (NOA); Nordeste (NEA) and Patagonia (PAT). RESULTS: High frequencies regional analysis showed the following significant results: PAM: severe hypospadias; CEN: spina bifida, microtia, cleft lip with cleft palate, polycystic kidney, postaxial polydactyly and Down syndrome; CUY: postaxial polydactyly; NOA: omphalocele, gastroschisis, cleft lip without cleft palate, cleft lip with cleft palate, anorectal atresia/stenosis, indeterminate sex, preaxial polydactyly and pectoral agenesis; PAT: cleft lip without cleft palate. CONCLUSION: Out of the 27 congenital anomalies analyzed, fourteen showed a frequency significatively higher in one or more regions.