SHORT-TERM FEVER-RANGE HYPERTHERMIA MODULATES ANTIBACTERIAL AND PRO-INFLAMMATORY NEUTROPHIL RESPONSE

KEITELMAN, IRENE A.; GIAI, CONSTANZA; LEDO, CAMILA; GEFFNER, JORGE R.; GOMEZ, MARISA I; SHIROMIZU, CAROLINA M.; ROSSO, DAVID; GUZMAN, MAURICIO; JANCIC, CAROLINA; SABBIONE, FLORENCIA; FUENTES, FEDERICO; MIGLIO RODRIGUEZ, MAXIMILIANO; GALLETTI, JEREMÍAS; TREVANI, ANALÍA S.

Tucumán

Congreso; LVII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2019

Sociedad Argentina de Inmunología

Fever is a physiological and evolutionary conserved response to infection and injury that takes place as a consequence of the temporary resetting of the body?s thermostatic set point. During the course of fever, neutrophils become exposed to temperatures between 38°C-41°C. We have previously determined that short-term fever-range hyperthermia (STFRH; 1h at 39.5°C) promotes NETosis when neutrophils are exposed to PMA and the Gram negative bacteria P.aeruginosa. To further investigate STFRH impact, neutrophils isolated from healthy donors were incubated at 37°C or 39.5°C for 1h, and then challenged with P.aeruginosa PAO-1 at 37°C for different times. Then, the impact of temperature on different neutrophil functions was determined. While STFRH moderately reduced P.aeruginosa-GFPphagocytosis (*p