M-TYROSINE EFFECT ON IMMUNOSUPPRESSION MURINE MODELS

ALEJANDRA DUARTE; RAÚL RUGGIERO; ARIEL STRAZZA; MARTÍN ISTURIZ; DANIELA MONTAGNA; PAULA CHIARELLA; BÁRBARA REARTE

CABA

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS 2017; 2017

Meta-tyrosine (m-tyr) is an isomer of tyrosine with anti-metastatic effects. This could be explained, in part, by the modulation of the inflammatory context in an immunosuppression (IS) state. We have studied the m-tyr effect on the immune response and the associated inflammatory context in two IS murine models. In the first one, BALB/c mice were immunosuppressed with increasing doses of LPS and treated with m-tyr. The second model consisted in the administration of m-tyr in advanced metastatic LMM3 tumor-bearing mice when IS was established and the subsequent challenge with a single dose of LPS. Humoral immune response, after immunization with sheep erythrocytes, was evaluated through a hemagglutination assay, citokines production by ELISA and splenic cell populations by flow cytometry. M-tyr enabled a significant increase of the antibodies titre when it was administered simultaneously and at the end of the schedule of LPS-induced IS. [Mean ± SEM, IS=4,78±3,1%; IS-mtyr=68,25±34,6% p