M-tyrosine effect on immunosuppression mice model

DUARTE, ALEJANDRA; RUGGIERO, RAÚL A.; STRAZZA, ARIEL R.; ISTURIZ, MARTÍN A.; MONTAGNA, DANIELA R.; CHIARELLA, PAULA; REARTE, BÁRBARA

CABA

Congreso; Reunión Conjunta de Sociedades de Biociencia; 2017

M-TYROSINE EFFECT ON IMMUNOSUPPRESSION MICE MODELMeta-tyrosine (m-tyr) is an isomer of tyrosine with anti-metastatic effects. This could be explained, in part, by the modulation of the inflammatory context in an immunosuppression (IS) state. We have studied the m-tyr effect on the immune response and the associated inflammatory context in two IS mice model. BALB/c mice were IS with increasing doses of LPS and treated with m-tyr. Then, humoral immune response, after challenge with sheep erythrocytes, and others immunological parameters were evaluated. Also, m-tyr was administered in advanced metastatic LMM3 carcinoma-bearing mice when IS was established; then, mice were inoculated with a single dose of LPS and inflammatory context was evaluated. M-tyr enabled a significant increase of the antibodies titre when it is administered simultaneously and at the end of the schedule of LPS-induced IS. [Mean ± SEM, control=100±12,5%; IS=4,78±3,1%**; IS-mtyr=68,25±34,6% **p