IMMUNE-CHECKPOINT INHIBITORS AND ANTI-TUMOR VACCINES SUPPORT THE IMMUNOSTIMULATORY THEORY OF CANCER

DANIELA MONTAGNA; RUGGIERO, RAÚL A.; CHIARELLA PAULA; VERMEULEN MÓNICA; STRAZZA, ARIEL RAMIRO

Buenos Aires

Congreso; Congreso de Sociedades de Biociencias; 2017

SAI,SAIC, SAFE;SAA, SAP; SAC..

Immune-checkpoint inhibitors and antitumor vaccines produce tumor-inhibitory and stimulatory effects on growing tumors dependingon the stage of tumor growth at which treatment was initiated. Theseparadoxical results can be understood by the immunosurveillancepostulates but might be explained by the Immune Stimulatory Theoryof Cancer, that was originally proposed on the basis that theimmune response (IR) induced by immunogenic murine tumors wasnot monotonic but biphasic, with strong IR producing inhibition andweak IR inducing stimulation of tumor growth