PROTUMORAL PROPERTIES OF NEUTROPHIL EXTRACELLULAR TRAPS (NETS) IN CHRONIC LYMPHOCYTIC LEUKEMIA

SABBIONE, FLORENCIA; ALMEJÚN, BELÉN; BORGE, MERCEDES; PODAZA, ENRIQUE; COLADO, ANA; BEZARES, FERNANDO; TREVANI, ANALIA; RISNIK, DENISE; ELIAS, ESTEBAN; FERNÁNDEZ GRECCO, HORACIO; GIORDANO, MIRTA N.

Mar del Plata

Congreso; Reunión anual de la Sociedad Argentina de Inmunología; 2016

We previously reported that PMN from CLL patients areprone to release extracellular traps (NETs) in response to2/A. +n the present YorM Ye extended these findings usingionomycin (1µg/ml) or TNF-α (10 ng/ml) plus LPS (100ng/ml) to induce NETosis. We found higher concentrationsof DNA and increased elastase activity in supernatantsfrom CLL-PMN compared to those from healthy donors(HD) PMN (n=6, p