Clinical and laboratory detection of transient neutralizing antibodies in severe von Willebrand disease on long term prophylaxis

SANCHEZ-LUCEROS A; ALBERTO MF; KEMPFER AC,; WOODS AI,; BLANCO A,; GROSSO SH,; ROMERO ML,; LAZZARI MA; BERMEJO E,; MESCHENGIESER SS

Toronto (Ontario)

Congreso; XXV ISTH Congress; 2015

International Society on Thrombosis and Haemostasis

Patients with type 3 VWD and some severe type 2 and type 1 VWD may benefit from long term prophylaxis (LTP) when bleeding is frequent and severe. Neutralizing antibodies to VWF have been reported in 10% ? 15% of VWD type 3 patients