Controlled HIV-HCV Viremia and Immune-Reconstitution are Associated with Slow Progression of Liver Disease in Co-infected Hemophilic Patients After 30 Years of Follow-Up

MONZANI MARIA CECILIA; CORTI MARCELO; NEME DANIELA; CHUIT ROBERTO; BADANO MARÍA NOEL; GUALTIERI ARIEL; TEZANOS PINTO; DE ELIZALDE DE BRACCO, MARÍA M.; ALOISI NATALIA; PARODI CECILIA; PRIMIANI LAURA; BARÉ PATRICIA

Japanese Journal of Gastroenterology and Hepatology

Japanese Journal of Gastroenterology and Hepatology

Año: 2020

2435-1210

1.1. Introduction and aim: Controversial results have been reported about the progressionof liver disease in HIV-HCV coinfected populations. The purpose of this study is to assesslong-term liver disease progression in a group of coinfected patients with hemophilia.1.2. Materials and Methods: From 1995 to 2015, liver disease was assessed through enzymelevels, platelet counts, Hepatitis C and HIV viral loads (VL), and CD4+T cell counts. Evolution of the APRI liver index was used to estimate hepatic disease (APRI > 1.0 indicatingsevere fibrosis).1.3. Results: 2005-2015 proportional liver-related mortality was below 17% while AIDSand other causes including hemorrhagic events reached 42% each. APRI index >1.0 wasfound in 3 of 32 (9%) patients alive, showing significant liver disease after more than 30years of infection. Analyzing the evolution of liver disease markers, liver enzymes increasedsignificantly only in those patients with detectable HIV and /or HCV VL (for AST and ALT,p