IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Common Variable Immunodeficiency and Circulating TFH
Autor/es:
DIEGO S. FERNÁNDEZ ROMERO; MALBRAN, ALEJANDRO; GALASSI NORA; MARTA FELIPPO; ANA CORAGLIA; MARÍA CECILIA JURI; BRACCO MM
Revista:
Journal of Immunology Research
Editorial:
Hindawi Publishing Corporation
Referencias:
Lugar: London; Año: 2016 vol. 2016 p. 1 - 10
ISSN:
2314-8861
Resumen:
CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.