TAM RECEPTOR SIGNALING IN IMMUNE HOMEOSTASIS

CARLA V. ROTHLIN; EUGENIO ANTONIO CARRERA SILVA; LIDIA BOSURGI; SOURAV GHOSH

ANNUAL REVIEW OF IMMUNOLOGY

ANNUAL REVIEWS

Lugar: Palo Alto, California; Año: 2015 vol. 33 p. 355 - 391

0732-0582

The TAM receptor tyrosine kinases (RTKs) - TYRO3, AXL and MERTK ?together with their cognate agonists, GAS6 and PROS1, play an essential role inthe resolution of inflammation. Deficiencies in TAM signaling have beenassociated with chronic inflammatory and autoimmune diseases. Threeprocesses regulated by TAM signaling may contribute, either independently orcollectively, to immune homeostasis: the negative regulation of the innateimmune response, the phagocytosis of apoptotic cells and the restoration ofvascular integrity. Recent studies have also revealed the function of TAMs ininfectious diseases and cancer. Here, we review the important milestones in thediscovery of these RTKs and their ligands and the studies that underscore thefunctional importance of this signaling pathway in physiological immune settingsand disease.