ININFA 02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
D1 and D2 dopamine receptor antagonists effects on levodopa-induced dyskinesias
Autor/es:
MARIANO SABORIDO; IRENE TARAVINI; CELIA LARRAMENDY; GUSTAVO MURER; OSCAR GERSHANIK
Lugar:
Tandil, Argentina
Reunión:
Congreso; Cuadragésima Reunión Anual de la Sociedad Argentina de Farmacología Experimental; 2008
Institución organizadora:
Sociedad Argentina de Farmacología Experimental (SAFE)
Resumen:
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A common and troublesome
complication of L-dopa therapy in Parkinsons disease is the
development of L-dopa-induced dyskinesias (LID). To evaluate if it is possible
to separate the generation of LID from the motor response induced by L-dopa, rats
with severe lesion of the nigrostriatal pathway were treated during 12 days
with L-dopa. Once LID were established, rats were treated with increasing doses
of SCH-23390 (D1 antagonist) or raclopride (D2 antagonist) in order to obtain a
dose that ameliorated LID without interfering with the motor response. We found
that SCH-23390 at a dose >0.005mg/kg ameliorates the severity of LID.
However, at these doses also the motor response evaluated by means of
contralateral rotations were also reduced. On the other hand, we were not able
to find a dose of raclopride that reduced the LID score induced by L-dopa. This
was probably because of the very low doses used here. These data in part
supports the idea that once dyskinesias are established it is not possible to
separate its generation from the motor response induced by a L-dopa.
