THE GABAB RECEPTORS MODULATES DYSPHORIC MANIFESTATIONS INDUCED BY MECAMYLAMINE-PRECIPITATED NICOTINE WITHDRAWAL IN MICE

VARANI A.P.; PEDRÓN V.T.; AON AJ; BETTLER B.; MALDONADO R.; BALERIO G. N

Chicago

Congreso; 45th Annual Meeting Society for Neuroscience; 2015

Society for Neuroscience

A growing body of evidence suggests that GABAB receptors modulate the addictive properties of nicotine, the main component of tobacco that produces dependence. In our study, complementary genetic and pharmacological approaches were used to test the hypothesis that the GABAB receptors modulate aversive motivational states associated with nicotine dependence in mice. For this purpose, the expression of the conditioned place aversion induced by mecamylamine-precipitated nicotine withdrawal was investigated in baclofen (GABAB agonist) and 2-OH-saclofen (GABAB antagonist) pretreated mice (pharmacological approach) and in GABAB1 knockout mice (genetic approach). Interestingly, baclofen prevented (p