Role of manganase as mediator of central nervous system: Alterations in experimental portal hypertension

JUAN PABLO PRESTIFILIPO; SILVINA TALLIS; AMALIA DELFANTE; PABLO SOUTO; JUAN CARLOS PERAZZO; GABRIELA BEATRIZ ACOSTA

Portal Hypertension. Causes and Complications

InTech - Open Access Publisher

Lugar: Slavka Krautzeka 83/A. 51000 Rijeka, Croatia; Año: 2012; p. 121 - 132

A new contribution that arises from our results is that the sharp effects that the Mn+2 produce on the aminoacidergic neurotransmitter can be opposite to the chronic effects (data not shown). In this way, when the Mn+2 accumulates in the synapis it produces a consistent neuropathy with an excitocitotoxic effect, suggesting that the mechanism of glutamate is involved in the development of the pathology described by the Mn+2. The results of the present work suggest that the Mn+2 would operate at the same time on the neurons GABAergic and glutamatergic hypothalamus that form a part of a network neuronal autoregulation.