ININFA 02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Validated HPLC method for Cynarin determination in biological samples
Autor/es:
ALONSO MR., GARCÍA MC., GARCÍA BONELLI C., FERRARO G., RUBIO M.
Revista:
ACTA FARM. BONAERENSE
Editorial:
Colegio Farmacéutico de la Prov. de BsAs
Referencias:
Año: 2006 vol. 25 p. 267 - 270
ISSN:
0326-2383
Resumen:
SUMMARY. A simple and sensitive method for the determination of cynarin is described and partially validated. The assay was used to determine the pharmacokinetic profile of cynarin after Wistar rat intravenous administration. Cynarin was isolated from rat plasma by solid-phase extraction. Separations were performed by reversed-phase high-performance liquid chromatography with ultraviolet detection.
