EVALUATION OFTELOMERE LENGTH IN WOMEN WITH POLYCYSTIC OVARY SYNDROME AND ITS ASSOCIATION TO METABOLIC SYNDROME, OBESITY AND HIPERANDROGENISM

ANDREA MILLAN; MARIELA VELAZQUEZ; GISELLE ADRIANA ABRUZZESE; SILVINA COCUCCI; GUSTAVO FRECHTEL; ALICIA BEATRIZ MOTTA; MAILEN ROJO; ANDREA ELENA; GLORIA CERRONE

Mendoza

Congreso; II Congreso Internacional en Medicina Traslacional; 2019

Universidad de Cuyo

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among young women. Telomere shortening is involved in the replicative capacity of a cell, considered as a marker of cellular aging. We aimed to determine the absolute Telomere Length (aTL) in women with PCOS and study their association with Metabolic Syndrome (MetS) and the presence of obesity and Hyperandrogenism (HA), in comparison with healthy controls. We studied 130 women with POCS and 86 age-matched healthy control women. Biochemical, clinical, anthropometric hormonal parameters have been measured. The aTL was performed on genomic DNA from peripheral blood leukocytes by Real Time PCR absolute quantitative method. Statistical analysis was carried out by one-way ANOVA and linear regression. Results: The whole sample (PCOS and Controls) showed an inverse relationship between aTL and age (p=0.004). Mean aTL was significantly higher in metabolically healthy PCOS patients compared to healthy control (p<0.001). Moreover, we found higher aTL in hyperandrogenic women with PCOS as compared to non hyperandrogenic women with PCOS and Controls (p=0.004). Also, higher aTL were observed in PCOS non obese women when compared to obese woman with PCOS and Controls (p<0.001). In PCOS patients we found a decrease in aTL with the presence of obesity (p=0.024; r = -4.71; 95% CI r = -8.78 / -0.63) and with the progressive increase in the MetS components (p=0.013; r = -1.99; 95% CI r = -3.56 / -0.43). In conclusion, aTL presents an inverse relationship withageinthe studied population. The study suggests that metabolic syndrome, obesity and HA contributed to the aTL in PCOS women. A lower aTL was associated with presence of MetS components and obesity, while biochemical HA was associated with higher aTL. Our results contribute to knowledge about the role of LT in the pathophysiology of PCOS.