IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CHLORPYRIFOS PROMOTES THE MIGRATION OF BREAST CANCER CELLS ACTIVATING C-SRC, AKT, GSK-3 beta AND p38 PATHWAYS
Autor/es:
SOLEDAD HIELPOS; ANDREA RANDI; MARIANELA LASAGNA; MARIANA MARDIROSIAN; MARIEL NUÑEZ; CLARA VENTURA ; NOELIA MIRET; CLAUDIA COCCA
Lugar:
Virtual
Reunión:
Congreso; Reunión Anual de Sociedades de Biociencias; 2020
Institución organizadora:
Sociedad Argentina de Investigación Clínica, Sociedad Argentina de Fisiología y Sociedad Argentina de Inmunología
Resumen:
Chlorpyrifos (CPF) is a pesticide whose effects on breast cancer risk are not clear. Our aim was to analyze if CPF promotes migration and the pathways involved in MCF-7 and MDA-MB-231 cell lines. Migration was evaluated by 2D (wound healing and Boyden Chamber assays) and 3D assays (multicellular spheroids). c-Src, AKT, P38 and GSK3-β were studied by Western Blot. In MCF-7 cells, 0.05 µM CPF induced the migration after 48 h (p
