IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Dual galectin-8 and ALCAM silencing delays triple negative breast cancer progression
Autor/es:
CAGNONI, ALEJANDRO J.; SANCHEZ TERRERO, CLARA; MARIÑO, KARINA V.; FERRAGUT, FÁTIMA; TRONCOSO, MARÍA F.; VANZULLI, SILVIA I.; ELOLA, MARÍA TERESA; COLOMBO, L. L.; WOLFENSTEIN-TODEL, C.; RABINOVICH, GABRIEL A.
Lugar:
BUENOS AIRES
Reunión:
Simposio; BUENOS AIRES BREAST CANCER SYMPOSIUM; 2021
Institución organizadora:
BA BREAST CANCER SYMPOSIUM
Resumen:
Triple-negative breast cancer (TNBC) comprises 10-15% of breast tumors, and lacks targeted therapy. Galectin-8 (Gal-8) is a tandem-repeat type galectin involved in cell adhesion and migration, angiogenesis and tumor progression. Here, we studied the tumorigenic properties of Gal-8 and its ligand ALCAM/CD166 in TNBC. We silenced both Gal-8 and ALCAM in MDA-MB-231 cells with specific (MDA-shGal8 and MDA-shALCAM, respectively) or scrambled shRNA lentiviral particles (MDA-shControl). Interestingly, both MDA-shALCAM (p
