IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Disruption of skin homeostasis activates a lectin-driven circuitry that controls immunopathology at the cross-roads of cancer and inflammatory psoriatic disease
Autor/es:
LAPORTE N; GATTO SG; TRONCOSO MF; CERLIANI JP; ABBA MC; PÉREZ SÁEZ JM; SUNDBLAD V; PINTO N; MORALES RM; BACIGALUPO ML; RABINOVICH GA
Reunión:
Congreso; Reunión de Sociedades de Biociencias; 2020
Resumen:
Disruption of skin homeostasis by environmental insultseventually activates pathologic circuitries leading to inflammationand carcinogenesis. Here we report essentialroles of Galectin-7 (Gal-7), a b-galactoside-binding proteinpreferentially expressed in keratinocytes (KCs), in skincarcinogenesis and inflammatory disorders. In a chemicallyinduced carcinogenesis model, mice constitutivelyover-expressing Gal-7 in KCs (Tg46 mice) showed highernumber (p
