CHRONIC ADMINISTRATION OF AN AT2R SYN-THETIC AGONIST INCREASES INSULIN SENSITIVITY IN MICE

FERNANDO P DOMINICI; CERVINO IA; MUÑOZ MC; TOBLLI JE; CAROLINA GIL ; DIEGO T. QUIROGA J

Congreso; LXII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2017

The renin-angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effect, while the an-giotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against insulin resistance and type 2 diabetes. In this study, we explored the role of AT2R in the control of insulin action. To that end, C57Bl/6 mice were administered the non-pep-tidic AT2R agonist C21 for 12 weeks (1 mg/kg per day; i.p. injec-tion; n=12); vehicle treated animals were used as control (n=12). One week before to the sacrifice, glucose and insulin tolerance tests were performed, which showed increased glucose tolerance and insulin sensitivity in C21 mice (n=8; p