2008 The anticancer action of plant polyphenols in Hodgkin`s lymphoma cells.

G.G. MACKENZIE; N. QUEISSER; M.L. WOLFSON; N.P. DECKER; C.G. FRAGA; A.M. ADAMO; P.I. OTEIZA

India

Congreso; International Conference on “Free Radicals & Natural Products in Health” & Seventh; 2008

The Society for Free Radical Research

Although treatment of Hodgkin`s lymphoma (HL) with a multi-drug approach has been very succssful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Thus, the current goal in HL treatment is to foind therapies that specifically target constitutively deregulated signaling cascades, such as NF-B and STAT3, which cause Hodgking and Reed-Sternberg (H-RS) cell proliferation and resistance of apoptosis.  We are investigating the capacity of several polyphenols, i.e.(-)epicatechin (EC), dimeric procyaidin B2 (B2), and curcumin to inhibit NF-B and STAT3, and prevent H-RS cell proliferation and induce apoptotic cell death. In H-RS cells, EC ad B2 inhibited NF-B but did not affect STAT3 activation, causing a moderate decrease in H-RS cell viability (15-40%). EC and B2 specifically acts inhibiting NF-kB by preventing the binding of the active NF-kB to the DNA. Curcumin induced cell cycle arrest in G2-M and apoptotic cell death, causing a significant reduction (80-97%) in H-Rs cell viability.  The present results stress the concep that several signaling pathways should be considered when designing new therapies for HL, and that select polyphenols can be relevant value in the targeted treatment of HL.