Analysis of the interaction between the RNA-dependent RNA polymerase (L protein) of Tacaribe virus and its inhibitor the Z-protein

CRISTINA MARINO BUSLJE; MAXIMILIANO WILDA; MARIA TEREZA FRANZE; JOSE MARIA DELFINO

Buenos Aires

Congreso; II Jornadas Iberoamericanas de Bioinformática; 2006

CYTED. Red Iberoamericana de Bioinformatica

  Tacaribe virus (TV) is the prototype of the New World group of arenaviruses. Within this group the viruses form three phylogenetically distinct clades, one of which includes TV together with the four known South American pathogens that produce severe hemorrhagic disease: the viruses Junin, Machupo, Guanarito and Sabia. TV, like all arenaviruses, is an enveloped virus containing two single-stranded RNA segments called S and L. The S RNA contains two genes encoding respectively the nucleoprotein (N, 64 kDa) and the glycoprotein precursor (GPC, 55 kDa) while the L RNA encodes the RNA-dependent RNA polymerase (L protein, 240 kDa)  and a small protein with a RING finger motif (Z ,11 kDa)