Caloric restriction recovered cerebellar motor and cognitive abilities in aged rats

PEREIRA SORROCHE BRUNA; FERRAMOLA MARIANA; MARTIN MAURICIO; CASTRO PASCUAL IVANNA; ALTAMIRANO FERNANDO; DELGADO MARCELA; CURZEL FLORENCIA; LACOSTE GABRIELA; ANZULOVICH ANA CECILIA

Buenos Aires

Congreso; XXXV Annual (Virtual) Meeting of the Argentinian Society for Neuroscience Research; 2020

SOCIEDAD ARGENTINA DE NEUROCIENCIAS

The beneficial effects of CR would work through epigenetic processes, but this is largely unexplored. Here, we examine the hypothesis that CR recovers learning and motor coordination associated to changes in Bdnf and TrkB DNA methylation, in old rats. For that, male Holtzman rats -young (3-mo-old, n=8), old (22-mo-old, n=9), both fed ad-libitum, and 18-mo-old rats fed a 40% calorie restricted diet for 3 months (n=4)- were kept under 12h-light: 12h-dark, 22-24 °C and water ad-libitum. Performing the Single Reaching Pellet test, we observed that the percentage of the total success rate and the quality of the first attempt during performance are significantly lower in the old compared to the young and old rats with CR (p