GALECTIN-1DRIVEN TOLEROGENIC PROGRAMS AGGRAVATE YERSINIA ENTEROCOLITICA INFECTION BY REPRESSING ANTIBACTERIAL INMUNITY

RICARDO JAVIER ELICABE; ROBERTO DAVICINO; KARINA MARIÑO; BRENDA JOFRÉ; GABRIEL RABINOVICH; INGO AUTENRIETH ; SANTIAGO MENDEZ-HUERGO; JUAN CARLOS STUPIRSKI; SILVIA DI GENARO

Buenos Aires

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

SOCIEDADES DE BIOCIENCIAS

Yersinia Enterocolitica (Ye) Is An Enteropathogenic BacteriumThat Causes Gastrointestinal Disorders. To Subvert The Host?s ImmuneResponse, Ye Uses A Type Iii Secretion System And EffectorProteins, Called Yersinia Outer Proteins (Yops), That Modulate ActivationAnd Survival Of Immune Cells. In This Study, We Show ThatGalectin-1 (Gal-1), An Immunoregulatory Lectin Widely ExpressedIn Mucosal Tissues, Contributes To Ye Pathogenicity By UnderminingProtective Antibacterial Responses. We Found Higher ExpressionOf Gal-1 In The Spleen And Peyer?s Patches (Pps) Of MiceInfected Orogastrically With Ye Compared With Noninfected Hosts(P