CADMIUM INTOXICATION IN AORTA, LUNG AND CEREBELLUM: IS THE EFFECT ORGAN SPECIFIC?

ALVAREZ SM; PEREZ CHACA MV; GIMENEZ MS; MARTIN MOLINERO GD; GOMEZ NN; BOLDRINI GG; PIGUILLEM SN

Merlo, San Luis

Congreso; Reunión Anual de la Sociedad De Biología de Cuyo; 2017

Sociedad de Biología de Cuyo

Cadmium (Cd) is an environmental contaminant and affects several organs. We studied its effect on lung, prostate and aorta. Oxidative stress, apoptotic markers and histology studies were performed. 2 lots of Wistar rats were used. One group received regular water (Co) and one, 15ppm of Cd in the drinking water for 60 (Cd). Total RNA was isolated and cDNA was obtained. p47, SOD,NOX, nrf2, FAS L, Bax, Bcl 2 were determined by PCR. S28 was the internal control. The organs were fixed in Bouin and histological studies were performed. In aorta, Nox 2 increased (p