ANDROGEN DEFICIENCY AND BLEOMYCIN TREATMENT DISRUPT THE HOMEOSTASIS OF HEMATOLOGICAL PARAMETERS AND BLOOD PRESSURE

EGGEL MARIA LUZ; PEREZ CHACA MARIA VERONICA; CIMINARI MARIA EUGENIA; OCAÑA S; GOMEZ NIDIA NOEMI; SALINAS ELOY; ALVAREZ, SILVINA M

Villa de Merlo

Congreso; XXXV Reunion Anual de la Sociedad de Biologia de Cuyo; 2017

Sociedad de Biologia de Cuyo

Roles of sex hormones as modulators of lung function and disease have received significant attention. Bleomycin (Ble) is an anti-neoplastic agent used as first-line therapy in many human cancers treatment; however it induces pulmonary fibrosis. The present study used bleomycin-induced pulmonary fibrosis in Wistar rats to examine potential differences in physiological and pathological outcomes in control and castrated rats under two different doses. Adult male rats were divided in six groups: 1) control (Co); 2) Co + Ble I (doses: 1,5 mg/kg); 3) Co + Ble II (doses: 10 mg/kg); 4)Ca (castrated); 5)Ca + Ble I and 6)Ca + Ble II. After 40 days of treatment, rats were sacrificed. TBARS and catalase (CAT) were measured and histological analysis was performed in lung. Ca+Ble increased TBAR?S and CAT, with significant differences between Ca vs Ble I and Ble II (p