IMIBIO-SL   20937
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
EFFECT OF ANDROGEN ON THE ANTIOXIDANT DEFENSE SYSTEM IN AORTA OF MALE RAT
Autor/es:
ALVAREZ SILVINA M; OCAÑA S; GOMEZ NIDIA N; MUÑOZ VALERIA; PEREZ CHACA MARIA VERONICA; CIMINARI MARIA EUGENIA; SALINAS ELOY
Lugar:
Mar del Plata
Reunión:
Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigacion Clinica,; 2016
Institución organizadora:
SAIC
Resumen:
There are many studies of androgens effect on vascular toneand endothelial function, hoever fe of them focuses on reactiveoxygen species S generation and regulation by testosterone.The antioxidant defense system consist of enzymatic and nonenzymatic compounds. Among the latter e found copper, zinc orselenium. ne of the most important functions of zinc is its participationin the antioxidant defense system. The aim of this oras to study the effect of castration on antioxidant parameters inaorta male rats. oreover, e analyzed the antioxidant defensesystem hen n as administered as a nonenzymatic antioxidant.e tested the effect of androgen deprivation on the prooxidantantioxidant balance days after castration. istar male ratsg ere separated in five groups controls Co, controlssupplemented ith zinc Con, castrated Ca, castrated supplementedith testosterone CaT and castrated supplementedith testosterone and zinc CaTn for five days. After daysrats ere illed and aorta as obtained. A as extracted byusing Tzol. uclear factorerythroid related factor nrf,lutathion peroxidase x, and catalase CAT expression eredetermined by TC. S as the control. lood pressure asmeasured before castration and days post castration. loodcells count as realized. AA as used for statistical analysis.rf expression shoed a significant increase in Ca p. bu tCaT group did not reversed the effect. CAT expression did notchange in Ca but CaTn as significantly higher than Co andCa rats p.. px expression in Ca, CaT and Con andCaTn ere higher than Co group p.. lood pressuredid not change after castration and blood cells count didnt shoany difference beteen treatments. e conclude that androgendeprivation alters the prooxidantantioxidant balance in aorta. rfis n sensitive, hile x is influenced by testosterone and n.