Th17 and Tregs at Early HIV Infection Associate with Distinct Patterns of Disease Progression and Anti-HIV CD8+ Responses.

JULIANA FALIVENE; YANINA GHIGLIONE; NATALIA LAUFER; MARÍA EUGENIA SOCIAS; MARÍA JULIA RUIZ; PEDRO CAHN; OMAR SUED; HORACIO SALOMON; GABRIELA TURK; MARÍA MAGDALENA GHERARDI

Boston

Congreso; The annual Conference on Retroviruses and Opportunistic Infections (CROI); 2014

Th17 and Treg subsets have been related to HIV/SIV disease progression. Their role and direct relation with specific HIV-adaptive T-cell responses during primary HIV infection (PHI) are unexplored topics. Aim: To analyze Th17 and Treg subsets, their balance and correlation with clinical parameters, immune activation and specific anti-HIV responses during early infection.METHODOLOGY: PBMCs were obtained from 6 healthy donors (HDs) and 28 HIV infected-subjects: 6 elite controllers (ECs), 5 chronics (Chs), and 17 PHIs (within 6 months post-infection (mpi)). PHIs were classified as PHI