AN EXPERIMENTAL MODEL OF WESTERN DIET-INDUCED OBESITY RESEMBLES METABOLIC SYNDROME IN C57BL/6J MICE

DELLA VEDOVA,MC ; MUÑOZ, MD ; MORENO-SOSA, T; ; GOMEZ MEJIBA, SE; RAMIREZ, DC.; FUNES, AK; RINALDI TOSI , M; ARROYUELO M ; FORNES, MW

San Luis

Congreso; XXXII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2014

Sociedad de Biologia de cuyo

Chronic consumption of high-fat diets (HFD) and fructose (F), western diet, coincides with an increase in the prevalence of obesity and metabolic syndrome. However, animal models are needed to understand the molecular bases of this association. Herein we aimed at developing a mouse model of metabolic syndrome. To accomplish this aim we fed male C57BL / 6J mice (n = 6) for 16 weeks a HFD and tap water with 10% fructose (HFD + F); HFD + tap water (HFD), low-fat diet (LFD) with F (LFD+F); and LFD and tap water (LFD). Throughout the experiment food and water consumption, as well as body-weight gain were measured. At the end of the diet regime adiposity index and insulin resistance (ip.GTT) were determined. Our data showed that the HFD + F group was heavier (p