A COMPENSATORY ANTIOXIDANT-MECHANISM TRIGGERED BY DIETARY-SOYBEAN PROTEIN AGAINST CADMIUM-INDUCED NEUROTOXICITY: FOCUS IN THE HIPOCAMPUS

PLATEO PIGNATARI MG1,2, DELLA VEDOVA MC2, RAMÍREZ DC2, GIMÉNEZ MS1.

San Luis

Congreso; XXXII Reunion Cientifica Anual de la Sociedad de Biologia de Cuyo; 2014

Sociedad Biologia de Cuyo

A COMPENSATORY ANTIOXIDANT-MECHANISM TRIGGERED BY DIETARY-SOYBEAN PROTEIN AGAINST CADMIUM-INDUCED NEUROTOXICITY: FOCUS IN THE HIPOCAMPUS Plateo Pignatari MG1,2, Della Vedova MC2, Ramírez DC2, Giménez MS1. 1Laboratorio de Nutrición y Medio Ambiente y 2Laboratorio de Medicina Experimental y Terapéuticas. IMIBIO-SL. CONICETUniversidad Nacional de San Luis, San Luis, Argentina. Email: mgplateo@yahoo.com.ar Cadmium (Cd) is an important environmental contaminant and causes neurotoxicity. Soybean proteins in the diet have health-beneficial effects due to its antioxidant properties.This study was aimed to testing whether Cd in the drinking water causes oxidative stress in the hippocampus (Hp) and that this process can be modulated by a soybean-based diet. For that, we fed 4 groups of female Wistar-rats for 60 days as follows: 1:casein-based diet (CBD) + tap water; 2: CBD + tap water with 15 ppm Cd (as Cl2Cd); 3: soybean-based diet (SBD) + tap water; and 4: SBD + tap water with 15 ppm Cd. Water and food consumption, and body-weight-gain curves were not different between the four experimental groups. At the end of the diet period we measured parameters of oxidative stress in serum and Hp. In either group Cd exposure did not change the serum concentration of TBARS (thiobarbituric acid reactive substances), a marker of lipid-peroxidation (LPO). In rats fed a CBD, Cd reduced serum total antioxidant capacity?bleaching of ABTS+ (p