Levels and balance of TH17 and Treg CD4+ subsets during acute/early HIV infection are associated with distinct patterns of disease progression and specific anti-HIV CD8+ responses.

JULIANA FALIVENE; YANINA GHIGLIONE; NATALIA LAUFER; MARÍA EUGENIA SOCIAS; MARÍA JULIA RUIZ; PEDRO CAHN; OMAR SUED; HORACIO SALOMÓN; GABRIELA TURK; MARÍA MAGDALENA GHERARDI

Cordoba

Otro; Reunión Anual de la Sociedad Argentina de Inmunología; 2013

Sociedad Argentina de Inmunología (SAI)

Th17 and Treg subsets have been related to HIV/SIV disease progression. Their relation with specific HIV-adaptive T-cell responses during primary HIV-infection (PHI) is still unexplored. Aim: to analyze Th17 and Treg subsets, their balance and correlation with clinical parameters and specific anti-HIV responses during early infection. PBMCs were obtained from 6 healthy donors (HDs) and 22 HIV infected subjects: 6 elite controllers (ECs), 4 chronics, and 12 PHIs (within 6 months post-infection (mpi)) classified as "PHI