Understanding platelet-virus interaction

NEGROTTO, SOLEDAD; JAQUENOD DE GIUSTI, CAROLINA; ALBERDI, LUCRECIA; FONDEVILA, CARLOS; SCHATTNER, MIRTA; GOMEZ, RICARDO M.

Amsterdam

Congreso; XXIV Congress of the International Society of Thrombosis and Haemostasis; 2013

International Society of Thrombosis and Haemostasis

Although the direct interaction between viruses and platelets was described many years ago, it is not yet clear whether platelets, by taking up viruses, contribute to the dissemination of infection, to the host antiviral defense or both. The ssRNA Coxsackievirus B (CVB), classified as an Enterovirus of the Picornaviridae family, represent an excellent candidate to study the platelet-virus interaction as the coxsackie adenovirus receptor (CAR) is expressed on the platelet surface, the CVB replication cycle is short (