"MODULATION OF ANTIOXIDANT ENZYMES EXPRESSION BY ANDROGENS IN LUNG TISSUE"

PACHECO GUIÑAZÚ AB, CIMINARI ME, VALDEZ SR, ÁLVAREZ SM, GÓMEZ NN.

San Luis

Congreso; XXX Reunión Anual de la Sociedad de Biología de Cuyo; 2012

Sociedad de Biologia de Cuyo

Lungs are very susceptible to injury mediated by free radicals and lipid peroxidation. This injury involves various adhesive and proinflammatory molecules. Also, androgens play a physiological role in pulmonary function. We tested the effect of castration on the prooxidant-antioxidant balance and lung histoarchitecture. Wistar male rats (200±20g) were separated in three groups: controls (Co), castrated (Ca), and castrated supplemented with testosterone (Ca+T) for five days. After 30 days rats were killed. Lungs were processed for microscopy and Image J analysis system was used. Bronchoalveolar lavages were made and an increase in protein content was found (p