IMIBIO-SL   20937
INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES BIOLOGICAS DE SAN LUIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Correlación entre parámetros clínicos y de estrés oxidativo en la población infantil obesa de la ciudad de San Luis
Autor/es:
SANTILLÁN L., GIMÉNEZ M.S
Lugar:
Mendoza
Reunión:
Congreso; XXVIII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2010
Resumen:
Correlación entre parámetros clínicos y de estrés oxidativo en la población infantil obesa de la ciudad
de San Luis.
Autores:
Santillán L., Giménez M.S. Presentado en la
XXVIII Reunión Científica
Anual de la Sociedad de Biología de Cuyo, Octubre de 2010. Mendoza. Argentina y publicado
en Rev. Biocell
Resúmen: The increased oxidative stress (OS) may be
involved in the pathogenesis of cardiovascular disease (CHD). In obese children
increased ROS causes a decrease in antioxidant enzyme activity (AE). The
purpose of this study was to investigate the association between body mass
index (BMI) and its relationship with expression of mRNANRF-2, activity of AE,
OS and clinical parameters in obese children. Blood was drawn from 27 non-obese
children and 31 obese patients. Plasma was separated and determined fasting
glucose (FG), total cholesterol (TC), HDLc, LDLc, triglycerides (TG), HOMA,
diastolic (DBP) and systolic pressure (SBP), TBARS, paraoxonase (PON),
glutathione peroxidase (GPx) and catalase (CAT) as well as RT-PCR was performed
for quantification of NRF-2. Pearson index determined for the correlations
studied revealed a positive correlation between BMI and TC, TG, HDL-C, TBARS,
HOMA, systolic pressure and negative correlation between BMI and HDL, AE
activity and expression of NRF-2. In Obese children altering the balance of OS
contribute to an increased risk of CHD.