INBIRS   24491
INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Unidad Ejecutora - UE
capítulos de libros
Título:
Core promoter: A critical region where the hepatitis B virus makes decisions
Autor/es:
QUARLERI J
Libro:
World Clinical Hepatology
Editorial:
Baishideng Publishing Group Inc
Referencias:
Lugar: Pleasanton (CA); Año: 2015; p. 846 - 856
Resumen:
The core promoter (CP) of the viral genome plays an
important role for hepatitis B virus (HBV) replication as
it directs initiation of transcription for the synthesis of
both the precore and pregenomic (pg) RNAs. The CP
consists of the upper regulatory region and the basal
core promoter (BCP). The CP overlaps with the 3?-end
of the X open reading frames and the 5?-end of the precore
region, and contains cis-acting elements that can
independently direct transcription of the precore mRNA
and pgRNA. Its transcription regulation is under strict
control of viral and cellular factors. Even though this
regulatory region exhibits high sequence conservation,
when variations appear, they may contribute to the
persistence of HBV within the host, leading to chronic
infection and cirrhosis, and eventually, hepatocellular
carcinoma. Among CP sequence variations, those occurring
at BCP may dysregulate viral gene expression
with emphasis in the hepatitis B e antigen, and contribute
to disease progression. In this review these molecular
aspects and pathologic topics of core promoter
are deeply evaluated.