ERAP1 and PDE8A Are Downregulated in Cattle Protected against Bovine Tuberculosis

BIGI, FABIANA; BLANCO, FEDERICO CARLOS; KLEPP, LAURA INÉS; SORIA, MARCELO ABEL

JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

KARGER

Año: 2017 vol. 27 p. 237 - 245

1464-1801

Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.