RELATIONSHIP BETWEEN SHORT- AND LONG-TERM MEMORY AND SHORT- AND LONG-TERM EXTINCTION.

CAMMAROTA M, BEVILAQUA LR, ROSSATO JI, RAMIREZ M, MEDINA JH, IZQUIERDO I.

NEUROBIOLOGY OF LEARNING AND MEMORY

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2005 vol. 84 p. 25 - 32

1074-7427

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman"; mso-ansi-language:PT-BR; mso-fareast-language:PT-BR; mso-bidi-language:AR-SA;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not inXuence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the Wrst step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the Wrst CS-no US presentation.