Antifungal Activity of Heterothalamus alienus Metabolites

ADRIANA DEL V. PACCIARONI; MARIA DE LOS ANGELES GETTE,; MARCOS DERITA; LUIS ARIZA ESPINAR; ROBERTO R. GIL,; SUSANA A. ZACCHINO; GLORIA L. SILVA

PHYTOTHERAPY RESEARCH

John Wiley

Año: 2008 vol. 22 p. 524 - 528

0951-418X

The chemical study of Heterothalamus alienus gave rutin, spathulenol, (1R,7S)-germacra-4(15),5,10(14)-trien-1â-ol (1), sakuranetin (2), padmatin 3-acetate (3), (2R,3R)-dihydroquercetin-3’,4´,7-trimethyl ether (4), (2R,3R)-dihydroquercetin-4´,7-dimethyl ether (5), (2R,3R)-3-acetoxy-4´,5,7-trihydroxyflavanone (6), as the main components of an antifungal extract of the aerial parts of the plant. Compound 1 showed borderline activity with the strongest being against Epidermophyton floccosum (IC50 = 50-100 mg/ml); compound 2 showed strong activity against Microsporum canis and Trichophyton rubrum (IC50 = 25 mg/ml, respectively) that compared very well with amphotericin B (IC50 = 50mg/ml and 25 mg/ml, respectively) against these strains; compound 4 and 5 were active against T. rubrum and T. mentagrophytes (IC50 = 62.5 mg/ml, respectively for each compound) and also compared favorably with amphotericin B and ketoconazole. Rutin, spathulenol and the 3-acetylated flavanones 3 and 6 did not show antifungal activity.