INVESTIGADORES
CHULUYAN Hector Eduardo
artículos
Título:
Dendritic cells therapy confers a protective microenvironment in murine pregnancy
Autor/es:
MIRANDA S, LITWIN S, BARRIENTOS G, SZEREDAY L, CHULUYAN E, BARTHO JS, ARCK PC, BLOIS SM
Revista:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Editorial:
Oxford : Blackwell Scientific Publications
Referencias:
Año: 2006 vol. 64 p. 493 - 499
ISSN:
0300-9475
Resumen:
The fetal-placental unit is a semi-allograft and immunological
recognition of pregnancy, together with the subsequent response of the
maternal immune system, is necessary for a successful pregnancy.
Dendritic cells (DC) show a biological plasticity that confers them
special characteristics regulating both immunity and tolerance. Therapy
employing DC proved to diminish the abortion in the DBA/2J-mated CBA/J
females; however, the underlying mechanisms remain unknown. Here, we
evaluated whether DC therapy influences the presence of
immunoregulatory populations of cells at the fetal-maternal interface.
To address this hypothesis, we analysed the pregnancy-protective CD8,
gammadelta cell populations as well as transforming growth factor
(TGF)-beta1 and progesterone-induced blocking factor (PIBF) expression
at the fetal-maternal interface from abortion-prone female mice that
had previously received adoptive transfer of syngeneic DC. Syngeneic DC
therapy induced an increase in the number of CD8 and gammadelta cells.
Additionally, an upregulation of TGF-beta1 and PIBF expression could be
detected after DC transfer. We suggest that DC therapy differentially
upregulates a regulatory/protective population of cells at the
fetal-maternal interface. It is reasonable to assure that this
mechanism would be responsible for the lower abortion rate.